Dec 1, 2023

Congratulations to CPIN Faculty Dr. Shirely X.Y. Wu, Dr. Jeffrey Henderson, Dr. Paul Fraser and CPIN Trainee Elliya Park on their recent publication

CPIN Faculty News, Achievements, CPIN Trainee News, Achievements
Dr. Shirley Wu, Dr. Jeffrey Henderson, Dr. Paul Fraser, Elliya Park

Congratulations to CPIN Faculty Dr. Shirley Xiao Yu Wu (Professor, PHM, left), Dr. Jeffrey Henderson (Associate Professor, PHM, second left), Dr. Paul Fraser (Professor, MBP, second right), and CPIN Trainee Elliya Park (PhD Candidate, PHM, right) on their recent publication titled, "Brain-Penetrating and Disease Site-Targeting Manganese Dioxide-Polymer-Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways" in Advanced Science. 

Alzheimer’s disease, being the most common type of dementia, is characterized by the deposition of neurotoxic amyloid β and accumulation of hyper-phosphorylated tau in the brain. Since the reduction of these proteins may not be able to eliminate the root cause of AD, Park et al. have used multitargeted bioactive nanoparticles, more specifically, terpolymer-manganese dioxide nanoparticles functionalized with anti-amyloid β antibody (ab-TP-MDNP) to reduce hypoxia, neuroinflammation and oxidative stress, improving micro-vessel integrity, cerebral blood flow, and ultimately cerebral lymphatic clearance of amyloid β in the brain. This shift in the brain microenvironment due to multifunctional effects of Ab-TP-MDNP treatment improved cognitive function such as fear memory in TgCRND8 mice following treatment. This publication provides a suggestion for a new disease-modifying approach to tackling complex neurodegenerative diseases, such as Alzheimer's disease.

Read more about the publication here.