Bradly Wouters*
Email: brad.wouters@uhnresearch.ca
Princess Margaret Cancer Centre, University Health Network
Research interests: The overarching aim of our group is to discover ways to further personalize cancer treatment in order to improve individual patient outcomes. Our first specific aim is focused on understanding how conditions of low oxygen (hypoxia) influence the biology of glial tumour cells in ways that are critical for tumour cell behaviour and response to treatment. Within this area, 4 different adaptive responses to hypoxia are being investigated. We discovered new details about how each of these pathways influences the biology of hypoxic glioma cells, and we are now testing new therapeutic approaches that exploit this understanding. We also have developed novel methods for measuring hypoxia and the microenvironment of glial tumours that have promising research and clinical applications. The second major area of investigation utilizes novel technologies that can globally assess the importance of all genes in parallel. This technology is part of several studies to identify new therapeutic targets in brain cancers. Recent studies have continued to identify potential targets that could be useful either on their own or in combination with radiotherapy or chemotherapy.
Professor
Department of Medical Biophysics- SGS Appointment
Department of Radiation Oncology
University of Toronto
Academic Program Director
Radiation Biology, Department of Radiation Oncology
University of Toronto
Executive Vice President, Science and Research, University Health Network
Director, Hypoxia and Microenvironment Program, Ontario Cancer Institute
Senior Scientist, Princess Margaret Cancer Centre, University Health Network
Senior Investigator, Selective Agents Program, Ontario Institute for Cancer Research (OICR)
Links:
Lab Website
UHN Profile
U of T Profile: Medical Biophysics
U of T Profile: Radiation Oncology